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February 15, 1997Nucleic Acids ResearchOpen Access

Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein

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Authors

SASteven E. ApplequistKarolinska University Hospital MSManuel SelgFriedrich-Alexander-Universität Erlangen-Nürnberg CRChander RamanUniversity of Alabama at Birmingham

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Implication

First human UPF1 homolog identified; leaves open its therapeutic targeting in nonsense mutation disorders.

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Cite This Study

Applequist et al. (1997) studied this question.

synapsesocial.com/papers/6a7f2683b4cedf233c7c9cd4 https://doi.org/10.1093/nar/25.4.814

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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

1Effects of Nonsense Mutations on Nuclear and Cytoplasmic Adenine Phosphoribosyltransferase RNA1996 · 65 citations
2mRNA surveillance by the Caenorhabditis elegans smg genes.1993 · 480 citations
3Nonsense mutations inhibit splicing of MVM RNA in cis when they interrupt the reading frame of either exon of the final spliced product.1992 · 132 citations
4Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon.1995 · 289 citations