Key result
Significant paravalvular leak after TAVI was strongly associated with anaemia at 3 months (OR 8.31; 95% CI 2.06-33.50) and increased long-term mortality (HR 1.82; 95% CI 1.16-2.85).
Why the study?
The relationship between significant paravalvular leak after TAVI and anaemia, as well as their impact on prognosis, needed to be assessed.
Does significant paravalvular leak after TAVI increase the risk of anaemia and long-term mortality in patients undergoing TAVI?
Observational (n=788)
Yes
Does significant paravalvular leak after TAVI increase the risk of anaemia and long-term mortality in patients undergoing TAVI?
Odds Ratio: 8.31 (95% CI 2.06–33.5)
Significant paravalvular leak after TAVI is strongly associated with the development of anaemia at 3 months, which in turn is associated with doubled long-term mortality.
Supports closer anaemia monitoring after significant PVL but should not yet change practice; leaves open causality.
OBJECTIVE: The aim of this work is to assess the relationship between significant paravalvular leak (SPL) after transcatheter aortic valve implantation (TAVI) on anaemia and their impact on prognosis. METHODS: Observational analytic study developed at two university hospitals, including all consecutive patients who underwent TAVI during a 10-year period (2009 to 2018). A logistic regression model was created to determine independent predictors of anaemia at 3 months. Time to event outcomes were analysed with Cox regression. Median follow-up was 21.3±21.9 months. RESULTS: 788 patients were included. 5.3% had SPL. SPL was an independent predictor of anaemia 3 months after TAVI (OR: 8.31, 95% CI: 2.06 to 33.50). SPL and anaemia at 3 months were independently associated with long-term mortality (HR: 1.82, 95% CI: 1.16 to 2.85; HR: 2.07, 95% CI: 1.39 to 3.08). CONCLUSION: SPL is an independent predictor of anaemia at 3 months after TAVI, a condition that doubles long-term mortality. Our findings could explain in part the worse prognosis of SPL after TAVI. Further pathophysiological studies are necessary to explain this association.
No takes yet. Share an insight, caveat, or question.
López‐País et al. (2020) conducted an observational in Significant paravalvular leak after TAVI (n=788). Significant paravalvular leak (SPL) vs. No significant paravalvular leak was evaluated on Anaemia at 3 months (OR 8.31, 95% CI 2.06-33.50). Significant paravalvular leak after TAVI was strongly associated with anaemia at 3 months (OR 8.31; 95% CI 2.06-33.50) and increased long-term mortality (HR 1.82; 95% CI 1.16-2.85).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: