Population
Rat models of type-1 (streptozotocin-induced) and type-2 (Zucker Diabetic Fatty rats) diabetic cardiomyopathy
Comparison
Type-1 diabetes mellitus model vs Type-2 diabetes mellitus model
Design
Preclinical
Authors
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Rat model phenotypes should not yet change clinical practice; leaves open whether type-specific mechanisms warrant distinct human therapies.
Type-1 and type-2 diabetic cardiomyopathy in rat models exhibit distinct pathophysiological and functional profiles, with type-1 characterized by systolic dysfunction and severe apoptosis/fibrosis, and type-2 by diastolic stiffness.
Radovits et al. (2015) studied this question.
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