Key result
In children with hand, foot and mouth disease or herpangina, the presence of headache was a highly significant risk factor for developing neurologic complications (OR 10.75).
Observational (n=168)
Yes
Odds Ratio: 10.75 (95% CI 3.56–32.52)
p-value: p=<0.001
In pediatric patients with hand, foot and mouth disease or herpangina, headache and neurologic signs are strong independent predictors of severe neurologic complications.
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Headache may flag higher neurologic risk in pediatric HFMD or herpangina; hypothesis-generating and requires prospective validation before guiding care.
Kim et al. (2013) conducted an observational in Hand, foot and mouth disease (HFMD) or herpangina (HP) (n=168). Headache vs. Absence of headache was evaluated on Neurologic complications (aseptic meningitis, encephalitis, encephalomyelitis, or polio-like syndrome) (OR 10.75, 95% CI 3.56-32.52, p=<0.001). In children with hand, foot and mouth disease or herpangina, the presence of headache was a highly significant risk factor for developing neurologic complications (OR 10.75).
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