Why the study?
What are the clinical predictors for neurological involvement in children with hand, foot, and mouth disease?
Population
Children with hand, foot, and mouth disease admitted during outbreaks between 2000 and 2006
Design
Cohort
Authors
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May support selective CSF testing in high-risk pediatric HFMD; hypothesis-generating and requires prospective validation before practice change.
What are the clinical predictors for neurological involvement in children with hand, foot, and mouth disease?
Total duration of fever ≥3 days, peak temperature ≥38.5°C, and history of lethargy are independent clinical predictors of neurological involvement in children with hand, foot, and mouth disease.
Ooi et al. (2009) studied this question.
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