Key result
HEV71- and CVA16-IgM ELISAs demonstrated high sensitivity and successfully identified the specific enteroviral infection in 96.6% and 91.7% of cases respectively, serving as a convenient diagnostic tool for hand-foot-and-mouth disease.
Why the study?
Does IgM-capture ELISA accurately diagnose HEV71 and CVA16 infections in children with hand-foot-and-mouth disease?
Observational (n=305)
No
Does IgM-capture ELISA accurately diagnose HEV71 and CVA16 infections in children with hand-foot-and-mouth disease?
Effect estimate: 81.3% (95% CI 76.9-85.1)
IgM-capture ELISAs for HEV71 and CVA16 provide a convenient, cost-effective, and sensitive diagnostic tool for hand-foot-and-mouth disease in clinical settings.
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May aid specific HFMD diagnosis in children; leaves open prospective validation before routine clinical use.
Yu et al. (2012) conducted an observational in Hand-foot-and-mouth disease (HFMD) (n=305). IgM-capture ELISA for HEV71 and CVA16 vs. Real-time RT-PCR was evaluated on Positive predictive value of HEV71-IgM ELISA (81.3%, 95% CI 76.9-85.1). HEV71- and CVA16-IgM ELISAs demonstrated high sensitivity and successfully identified the specific enteroviral infection in 96.6% and 91.7% of cases respectively, serving as a convenient diagnostic tool for hand-foot-and-mouth disease.
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