Key result
The IgM anti-EV71 ELISA demonstrated a 94.1% sensitivity during the acute phase and 99.1% specificity in non-HFMD children, enabling reliable early diagnosis of EV71 infection.
Why the study?
Does an IgM anti-EV71 ELISA assay accurately detect early EV71 infection compared to RT-PCR or virus isolation?
Cross-Sectional (n=3,194)
Does an IgM anti-EV71 ELISA assay accurately detect early EV71 infection compared to RT-PCR or virus isolation?
The IgM anti-EV71 ELISA provides a highly sensitive and specific method for the rapid, early diagnosis of EV71 infection, which is crucial for managing outbreaks.
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Supports rapid EV71 diagnosis in outbreaks; leaves open prospective validation versus RT-PCR before routine use.
Xu et al. (2010) conducted a cross-sectional in Enterovirus 71 (EV71) infection (n=3,194). IgM anti-EV71 ELISA vs. RT-PCR or virus isolation was evaluated on Sensitivity of IgM anti-EV71 assay during the acute phase (95% CI 90.2-96.8). The IgM anti-EV71 ELISA demonstrated a 94.1% sensitivity during the acute phase and 99.1% specificity in non-HFMD children, enabling reliable early diagnosis of EV71 infection.