Key result
Transcutaneous electrical stimulation of the auricular branch of the vagus nerve significantly increased 6-minute walk test distance from 265.4 m to 376.4 m and improved clinical condition in patients with chronic coronary insufficiency and severe left ventricular dysfunction.
Why the study?
Does transcutaneous vagus nerve stimulation improve heart rate, functional capacity, and heat shock protein levels in patients with chronic coronary insufficiency and severe left ventricular dysfunction?
RCT (n=70)
Sham-controlled
Randomized into two groups of different sizes (63 vs 7)
No
Does transcutaneous vagus nerve stimulation improve heart rate, functional capacity, and heat shock protein levels in patients with chronic coronary insufficiency and severe left ventricular dysfunction?
Absolute Event Rate: 376.4% vs 213.6%
p-value: p=<0.05
Transcutaneous vagus nerve stimulation may attenuate heart rate and improve functional capacity in patients with severe ischemic heart failure.
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Supports transcutaneous auricular vagus stimulation to improve functional capacity in severe ischemic HF; extends neuromodulation evidence from this RCT.
Afanasiev et al. (2016) conducted an RCT in Chronic coronary insufficiency and severe left ventricular dysfunction (n=70). Pulsed electrical stimulation of the auricular branch of the vagus nerve vs. Sham therapy was evaluated on 6-minute walk test distance (meters) (p=<0.05). Transcutaneous electrical stimulation of the auricular branch of the vagus nerve significantly increased 6-minute walk test distance from 265.4 m to 376.4 m and improved clinical condition in patients with chronic coronary insufficiency and severe left ventricular dysfunction.
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