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May 5, 2015Journal of Diabetes & Metabolic DisordersOpen Access

Relationship of resting heart rate and physical activity with insulin sensitivity in a population-based survey

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Key result

Increased resting heart rate and lower levels of physical activity were both independently associated with increased insulin resistance (p < 0.0001).

Why the study?

Are resting heart rate and physical activity independently associated with insulin resistance and insulin secretion in a multiethnic cohort?

Population

1,327 participants of Native Hawaiian, Japanese, Filipino, Caucasian, and mixed ethnic ancestries from the…

Design

Cross-sectional

Authors

AGAndrew GrandinettiUniversity of Hawaiʻi at MānoaDLDavid MKI LiuJKJoseph Keawe‘aimoku KaholokulaUniversity of Hawaiʻi at Mānoa

Discussion

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Implication

May aid risk stratification; leaves open causal effects and intervention trials in multiethnic cohorts.

Study Design

Type

Cross-Sectional (n=1,327)

Multicenter

No

Structured PICO

Are resting heart rate and physical activity independently associated with insulin resistance and insulin secretion in a multiethnic cohort?

P
Population
1,327 non-diabetic adults from a multiethnic community in Hawaii evaluated cross-sectionally for the association of resting heart rate and physical activity with insulin resistance.
E
Exposure
Resting heart rate (RHR) and physical activity (PA) levels
O
Outcome
Insulin resistance estimated using the homeostasis model assessment for insulin resistance (HOMA-IR) and first phase insulin response estimated using the insulin secretion ratio (ISR)surrogate

Main Result

p-value: p=<0.0001

Increased resting heart rate and lower physical activity are independently associated with increased insulin resistance, suggesting cardiovascular fitness is an important factor in preventing metabolic risk.

Limitations

  • Cross-sectional design prevents causal attribution.
  • Use of self-reported physical activity may lead to exposure misclassification.
  • Medication use was not available for the main analysis.
  • Cross-sectional design precludes attributing causation
  • Use of self-report to estimate actual physical activity may lead to exposure misclassification
  • Medication use was not available for this analysis

Cite This Study

Grandinetti et al. (2015) conducted a cross-sectional in Insulin resistance (n=1,327). Resting heart rate and physical activity vs. Lower resting heart rate and higher physical activity was evaluated on Insulin resistance (HOMA-IR) (p=<0.0001). Increased resting heart rate and lower levels of physical activity were both independently associated with increased insulin resistance (p < 0.0001).

synapsesocial.com/papers/6a7f2efdda2615c795b3a952https://doi.org/10.1186/s40200-015-0161-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Heart rate in relation to insulin sensitivity and insulin secretion in nondiabetic subjects.2000 · 95 citations
  2. 2High Heart Rate1999 · 276 citations
  3. 3Early Autonomic Dysfunction in Glucose-Tolerant but Insulin-Resistant Offspring of Type 2 Diabetic Patients2003 · 56 citations
  4. 4Use and Abuse of HOMA Modeling2004 · 5,185 citations
  5. 5Vigorous Exercise, Fitness and Incident Hypertension, High Cholesterol, and Diabetes2008 · 107 citations