Why the study?
Does growth hormone treatment alter insulin sensitivity and metabolism in children with short stature?
Population
8 children with short stature and 8 healthy control children matched for age, sex, and Tanner stage
Comparison
Growth hormone (GH) 0.3 mg/kg/week for 6 months vs Baseline and healthy matched controls
Design
Cohort
Follow-up
6 months
Authors
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GH therapy was associated with reduced insulin sensitivity in short-stature children; leaves open net effects on growth versus metabolic risk.
Does growth hormone treatment alter insulin sensitivity and metabolism in children with short stature?
Growth hormone treatment in children with short stature induces compensatory hyperinsulinemia and reduces insulin sensitivity, which may beneficially augment anabolic effects on protein metabolism.
Heptulla et al. (1997) studied this question.