Key result
Sleeve gastrectomy in obese patients leads to adverse effects on bone tissue, characterized by significantly increased bone resorption, decreased bone mineral density, and elevated fracture risk.
Why the study?
Bariatric surgery treats obesity and metabolic comorbidities, but accumulating evidence indicates it exerts adverse effects on bone tissue, including increased bone resorption, decreased bone mineral density, and elevated fracture risk.
Does sleeve gastrectomy affect bone metabolism and bone mineral density in obese patients?
Does sleeve gastrectomy affect bone metabolism and bone mineral density in obese patients?
Sleeve gastrectomy in obese patients leads to significant bone loss and increased fracture risk, necessitating lifelong nutritional monitoring and calcium/vitamin D supplementation.
Should not yet change postoperative bone protocols; leaves open confirmation of fracture risk and prevention after sleeve gastrectomy.
In recent years, the global incidence of obesity has continued to rise, making obesity and its associated complications a serious threat to human health. Bariatric surgery, represented by sleeve gastrectomy (SG), has emerged as a crucial intervention for the treatment of obesity and related metabolic comorbidities. However, accumulating evidence indicates that bariatric surgery exerts multiple adverse effects on bone tissue, characterized by significantly increased bone resorption, decreased bone mineral density (BMD), and a consequent elevation in fracture risk. This review summarizes the effects of SG on BMD, bone turnover markers (BTMs), and bone microarchitecture in obese individuals, and comprehensively discusses the underlying mechanisms as well as corresponding clinical prevention strategies.
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Fan et al. (2026) conducted a review in Obesity. Sleeve gastrectomy was evaluated. Sleeve gastrectomy in obese patients leads to adverse effects on bone tissue, characterized by significantly increased bone resorption, decreased bone mineral density, and elevated fracture risk.
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