What question did this study set out to answer?

To investigate how dietary history and insulin administration influence the uptake and metabolism of l(+)-lactate and glucose in isolated perfused rat myocardium.

May 1, 1962Biochemical JournalOpen Access

Effects of insulin and diet on the metabolism of l(+)-lactate and glucose by the perfused rat heart

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Authors

JWJR WILLIAMSONJohnson Foundation

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Implication

Experimental study demonstrates changes in lactate and glucose metabolism in perfused rat hearts following insulin exposure and diet modifications, indicating metabolic regulation of cardiac fuel.

Key Points

To investigate how dietary history and insulin administration influence the uptake and metabolism of l(+)-lactate and glucose in isolated perfused rat myocardium.
Isolated rat hearts were perfused ex vivo to measure carbohydrate substrate utilization.
Lactate and glucose metabolic fluxes were evaluated under contrasting dietary regimens and insulin exposure.
Insulin exposure and dietary history modulate the utilization rates of both l(+)-lactate and glucose in cardiac tissue.
Nutritional conditioning shifts myocardial substrate selection between exogenous lactate and glucose.

Cite This Study

JR WILLIAMSON (1962) studied this question.

synapsesocial.com/papers/6a7f3325da7edfc28fb3aaa5 https://doi.org/10.1042/bj0830377

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Implication

Experimental study demonstrates changes in lactate and glucose metabolism in perfused rat hearts following insulin exposure and diet modifications, indicating metabolic regulation of cardiac fuel.

Effects of insulin and diet on the metabolism of l(+)-lactate and glucose by the perfused rat heart

Discussion

Member takes

Implication

Key Points

Cite This Study

Effects of insulin and diet on the metabolism of l(+)-lactate and glucose by the perfused rat heart

Discussion

Member takes

Implication

Key Points

Cite This Study

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