Key result
Molecular screening and virus isolation identified 55 EV68-positive cases among 6,307 pediatric respiratory specimens, suggesting that difficulty in EV68 isolation leads to underestimation.
Population
6307 respiratory specimens collected at pediatric clinics in Yamagata, Japan between 2005 and 2010
Design
Cross-sectional
Authors
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May underestimate EV68 burden by culture alone; leaves open optimal molecular testing strategies in pediatric respiratory surveillance.
Observational (n=6,307)
Yes
Molecular screening using RT-PCR reveals that enterovirus 68 infections are more prevalent than previously estimated by viral isolation alone.
Ikeda et al. (2012) conducted an observational in Acute respiratory infections (n=6,307). Enterovirus 68 (EV68) was evaluated on Identification of EV68-positive cases. Molecular screening and virus isolation identified 55 EV68-positive cases among 6,307 pediatric respiratory specimens, suggesting that difficulty in EV68 isolation leads to underestimation.
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