Key result
Enterovirus D68 seroprevalence reached a plateau of 93.4% to 99.1% among adults and ranged from 46.7% to 84.3% among children across six time points between 1976 and 2019.
Why the study?
The epidemiology of enterovirus D68, an enterovirus rarely identified in the 20th century, needed to be clarified.
Population
Individuals under and above 20 years old in Yamagata, Japan
Comparison
Sera collected in 1976, 1985, 1990, 1999, 2009, and 2019
Design
Seroepidemiological analysis
Authors
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Variable EV-D68 seroprevalence over decades warrants surveillance; leaves open prospective studies on immunity and outbreak risk.
Observational
This study demonstrates that EV-D68 was stably transmitted among children in Japan during the 20th century, despite rare clinical detection.
Itagaki et al. (2024) conducted an observational in Enterovirus D68 (EV-D68) infection. Enterovirus D68 exposure was evaluated on Neutralizing antibody-positive rates. Enterovirus D68 seroprevalence reached a plateau of 93.4% to 99.1% among adults and ranged from 46.7% to 84.3% among children across six time points between 1976 and 2019.
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