Key result
Neutralizing antibody titers against EV-D68 in asymptomatic children significantly increased immediately after a suspected outbreak (GMT 6.8 vs 3.6 pre-outbreak, P<0.0001) and gradually waned over 1 year.
Why the study?
To determine community children's immunity levels against EV-D68 infection before, during, and after a suspected outbreak in Sendai, Japan.
Observational (n=103)
No
Absolute Event Rate: 6.8% vs 3.6%
p-value: p=<0.0001
Seroepidemiological analysis confirmed an increase in EV-D68 immunity levels among community children during a suspected outbreak period, which gradually waned over the following year.
We previously reported a hospital-based epidemiological study on enterovirus (EV)-D68 infection among children during the autumn of 2015, which indirectly inferred an outbreak in Sendai, Japan. In this study, stocked sera of children (aged 0-6 years; without symptoms of infectious diseases) in the Sendai community collected during 4 periods (1 year before, 6 months before, immediately after, and 1 year after the possible outbreak period) were analyzed using the neutralization antibody titer assay to determine community children's immunity levels against EV-D68 infection. The immunity levels were confirmed to have increased during the possible outbreak period and to have gradually waned over 1 year without another outbreak. These results provide background information supporting the results of our previous hospital-based surveillance study.
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Kadji et al. (2019) conducted an observational in Enterovirus D68 infection (n=103). Suspected EV-D68 outbreak vs. Pre-outbreak period was evaluated on Geometric mean titer (GMT) of neutralizing antibodies against EV-D68 (p=<0.0001). Neutralizing antibody titers against EV-D68 in asymptomatic children significantly increased immediately after a suspected outbreak (GMT 6.8 vs 3.6 pre-outbreak, P<0.0001) and gradually waned over 1 year.
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