Key result
Point of care determination of CYP2C19 genotypes from buccal swabs demonstrated 100% concordance with MassARRAY genotyping in patients after percutaneous coronary intervention.
Why the study?
Does point-of-care CYP2C19 genotyping provide accurate results compared to standard MassARRAY genotyping in patients after percutaneous coronary intervention?
Observational (n=526)
No
Does point-of-care CYP2C19 genotyping provide accurate results compared to standard MassARRAY genotyping in patients after percutaneous coronary intervention?
Point-of-care CYP2C19 genotyping provides accurate and rapid results, supporting its potential utility for genotype-guided antiplatelet therapy in patients undergoing PCI.
Enables rapid CYP2C19 genotyping after PCI; leaves open whether genotype-guided therapy improves outcomes.
Distribution of cytochrome P450 2C19 enzyme gene (CYP2C19) variants affecting metabolism of clopidogrel was determined in 526 Czech patients after percutaneous coronary intervention using MassARRAY genotyping and compared to distribution in other populations of European descent. Fifty-three (10%) patients underwent parallel determination of CYP2C19 genotypes from buccal swabs by a point of care technique with 100% concordance to the main genotyping platform. Observed CYP2C19 genotypes were related to clopidogrel metabolism phenotypes and discussed in population context. Hereby, presented methodologies provide accurate CYP2C19 genotyping results in a relatively short time of one up to 12 h and may, therefore, find the relevant place in the field of genotype-guided antiplatelet therapy.
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Petřek et al. (2016) conducted an observational in Percutaneous coronary intervention (n=526). Point of care CYP2C19 genotyping vs. MassARRAY genotyping was evaluated on Concordance of CYP2C19 genotypes between point of care technique and MassARRAY. Point of care determination of CYP2C19 genotypes from buccal swabs demonstrated 100% concordance with MassARRAY genotyping in patients after percutaneous coronary intervention.
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