February 1, 1992Biochemistry

Interaction between the heavy and the regulatory light chains in smooth muscle myosin subfragment 1

View Full Paper

Ask AI

Bookmark

Population

Chicken gizzard myosin subfragment 1 (S-1)

Design

Preclinical

Authors

HOHirofumi OnishiTokyo Medical and Dental University TMTetsuo MaitaTokyo University of Science GMGenji MatsudaSasebo City General Hospital

Discussion

Member takes

Implication

Structural mapping of myosin cross-links offers no clinical implications; leaves open their role in phosphorylation-induced conformational changes.

Structured PICO

Population

Chicken gizzard myosin subfragment 1 (S-1)

Intervention

Treatment with zero-length chemical cross-linker 1-ethyl-3-[3-(dimethylamino)-propyl]carbodiimide (EDC) alone or in the presence of ATP or F-actin

Outcome

Cross-linking sites between heavy and regulatory light chainssurrogate

The COOH-terminal region of the regulatory light chain is located in the neck region of myosin, potentially playing a role in phosphorylation-induced conformational changes.

Cite This Study

Onishi et al. (1992) studied this question.

synapsesocial.com/papers/6a7f40415901e5fceb39d8bd https://doi.org/10.1021/bi00119a033

View Full Paper

Ask AI

Bookmark

Implication

Structural mapping of myosin cross-links offers no clinical implications; leaves open their role in phosphorylation-induced conformational changes.

Interaction between the heavy and the regulatory light chains in smooth muscle myosin subfragment 1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Interaction between the heavy and the regulatory light chains in smooth muscle myosin subfragment 1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider