April 22, 2003Neurology
Plasma levels of catechols and metanephrines in neurogenic orthostatic hypotension
Population
Patients with pure autonomic failure, Parkinson's disease with neurogenic orthostatic hypotension, or…
Design
Cross-sectional
Authors
Discussion
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Implication
Distinct catechol patterns may differentiate PAF, MSA+NOH, and PD+NOH; leaves open prospective validation before diagnostic adoption.
Structured PICO
P
Population
Patients with pure autonomic failure (PAF), Parkinson's disease with neurogenic orthostatic hypotension (PD + NOH), or multiple-system atrophy with NOH (MSA + NOH), and control subjects (PD lacking NOH or normal volunteers at least 35 years old).
C
Comparator
Control subjects (PD lacking NOH or normal volunteers at least 35 years old)
O
Outcome
Plasma levels of catechols (norepinephrine, epinephrine), dihydroxyphenylglycol (DHPG), metanephrines (normetanephrine, metanephrine), and cardiac sympathetic innervation assessed by 6-[18F]fluorodopamine PET scanningsurrogate
Different causes of neurogenic orthostatic hypotension exhibit distinct patterns of plasma catechols, metanephrines, and cardiac sympathetic innervation, reflecting different underlying pathophysiologies.
Cite This Study
Goldstein et al. (2003) studied this question.