Key result
Intravenous trimethaphan and yohimbine elicited significantly smaller blood pressure responses in patients with Parkinson disease and pure autonomic failure compared to multiple system atrophy.
Why the study?
Do hemodynamic responses to trimethaphan and yohimbine distinguish between different neurogenic orthostatic hypotension syndromes in patients with autonomic failure?
Population
88 patients with neurogenic orthostatic hypotension, including Parkinson disease with autonomic failure…
Comparison
Intravenous trimethaphan (TRI) or yohimbine (YOH) vs Comparison between disease groups
Design
Cross-sectional
Authors
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Supports research differentiation of autonomic failure syndromes; clinical diagnostic or therapeutic utility remains unproven.
Cross-Sectional (n=88)
Do hemodynamic responses to trimethaphan and yohimbine distinguish between different neurogenic orthostatic hypotension syndromes in patients with autonomic failure?
p-value: p=0.01, 0.03
Hemodynamic responses to trimethaphan and yohimbine can distinguish Parkinson disease with orthostatic hypotension and pure autonomic failure from multiple system atrophy, reflecting differences in sympathetic noradrenergic denervation.
Sharabi et al. (2006) conducted a cross-sectional in Neurogenic orthostatic hypotension syndromes (n=88). Intravenous trimethaphan or yohimbine vs. Multiple system atrophy (MSA) group was evaluated on Blood pressure response to trimethaphan and yohimbine (p=0.01, 0.03). Intravenous trimethaphan and yohimbine elicited significantly smaller blood pressure responses in patients with Parkinson disease and pure autonomic failure compared to multiple system atrophy.
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