Why the study?
Does therapeutic plasma exchange within 3 days of onset improve survival in patients with clopidogrel-associated TTP?
Population
50 cases of clopidogrel-associated thrombotic thrombocytopenic purpura reported between 1998 to 2002
Comparison
Therapeutic plasma exchange within 3 days of… vs Delayed or no therapeutic plasma exchange
Design
Cohort
Authors
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Early TPE may improve survival in clopidogrel-associated TTP; leaves open confirmation in randomized trials.
Does therapeutic plasma exchange within 3 days of onset improve survival in patients with clopidogrel-associated TTP?
Prompt therapeutic plasma exchange within 3 days of onset significantly improves survival in patients with clopidogrel-associated TTP.
Zakarija et al. (2004) studied this question.
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