Why the study?
To evaluate the association between common ACE gene SNPs and the risk of in-stent restenosis and response to ACE inhibitors in patients with stable CAD after stent implantation.
Does ACE gene polymorphism and ACE inhibitor administration affect the risk of in-stent restenosis in patients with stable coronary artery disease after PCI?
Does ACE gene polymorphism and ACE inhibitor administration affect the risk of in-stent restenosis in patients with stable coronary artery disease after PCI?
The ACE gene D allele is associated with a higher risk of in-stent restenosis, but ACE inhibitor therapy appears to have a protective effect against restenosis specifically in patients with the DD genotype.
Purpose: To evaluate the association between common single nucleotide polymorphisms (SNPs) in angiotensin converting enzyme (ACE) gene and the risk of in-stent restenosis (ISR) and/or the response to angiotensin converting enzyme inhibitor ACEI in individuals with stable coronary artery disease (CAD) after stent implantation. Methods: The total population of this study consisted of 200 Egyptian individuals divided into 2 groups - in-stent restenosis (ISR) and non ISR group). Genomic DNA was withdrawn from EDTA whole blood applying a spin column approach and ACE gene insertion/deletion (I/D) polymorphisms were determined by polymerase chain reaction (PCR). Results: Carriers of allele D of ACE gene were significantly more liable to ISR occurrence. However, carriers of allele I were significantly more liable to ISR occurrence after administration of ACEI. There is a negative interaction between DD genotype of ACE gene and ACEI administration on ISR after percutaneous coronary intervention (PCI). However, there is a positive interaction between II and ID genotype of ACE gene and ACEI administration on ISR after PCI with bare metal stents (BMS). Conclusion: It is beneficial to implement ACEI in therapeutic regimen in individuals with ID or II genotypes of ACE gene, especially with BMS implementation.
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El-Aziz et al. (2022) studied this question.
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