June 1, 1989Journal of Cerebral Blood Flow & MetabolismOpen Access

Direct Chemical Measurement of the λ of the Lumped Constant of the 14 CDeoxyglucose Method in Rat Brain: Effects of Arterial Plasma Glucose Level on the Distribution Spaces of 14 CDeoxyglucose and Glucose and on λ

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Population

Rat brain model

Comparison

Programmed intravenous infusions of… vs Normoglycemic conditions

Design

Preclinical

Authors

KMKentaro MoriWashington University in St. Louis NCNancy F. CruzNational Institutes of Health GDGerald A. DienelUniversity of New Mexico

Discussion

Member takes

Implication

Lambda may vary in severe hypoglycemia; leaves open [14C]DG method accuracy in hypoglycemic animal models.

Structured PICO

Population

Rat brain model

Intervention

Programmed intravenous infusions of [14C]deoxyglucose and glucose to produce constant arterial concentrations (graded hyperglycemia and hypoglycemia)

Comparator

Normoglycemic conditions

Outcome

Distribution spaces for [14C]deoxyglucose and glucose, and the value of lambdasurrogate

The lumped constant factor lambda in the [14C]deoxyglucose method is stable in normoglycemia and hyperglycemia but rises sharply in severe hypoglycemia in rat brains.

Cite This Study

Mori et al. (1989) studied this question.

synapsesocial.com/papers/6a7f4f22aa5aedc584ad021e https://doi.org/10.1038/jcbfm.1989.48

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Direct Chemical Measurement of the λ of the Lumped Constant of the 14 CDeoxyglucose Method in Rat Brain: Effects of Arterial Plasma Glucose Level on the Distribution Spaces of 14 CDeoxyglucose and Glucose and on λ

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Direct Chemical Measurement of the λ of the Lumped Constant of the 14 CDeoxyglucose Method in Rat Brain: Effects of Arterial Plasma Glucose Level on the Distribution Spaces of 14 CDeoxyglucose and Glucose and on λ

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider