What question did this study set out to answer?

Estimate the effectiveness of seasonal influenza vaccination in preventing influenza-associated hospitalizations among adults during the 2015–2016 influenza season.

December 13, 2018The Journal of Infectious DiseasesOpen Access

Prevention of Influenza Hospitalization Among Adults in the United States, 2015–2016: Results From the US Hospitalized Adult Influenza Vaccine Effectiveness Network (HAIVEN)

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Authors

JFJill M. FerdinandsIntermountain Healthcare MGManjusha GaglaniIntermountain Healthcare EMEmily T. MartinCincinnati Children's Hospital Medical Center

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Implication

Test-negative case-control study demonstrates reduced hospitalization risk following influenza vaccination in adults, indicating substantial protection against severe illness in high-risk groups.

Key Points

Estimate the effectiveness of seasonal influenza vaccination in preventing influenza-associated hospitalizations among adults during the 2015–2016 influenza season.
Conducted a test-negative case-control study across 8 US hospitals enrolling adults aged ≥18 years admitted with acute respiratory illness.
Identified cases and controls using reverse transcription-polymerase chain reaction testing for influenza virus.
Calculated vaccine effectiveness using multivariable logistic regression adjusted for age, comorbidities, frailty, and vaccination history.
Evaluated 236 influenza-positive cases and 1231 test-negative controls (mean age 58 years; >90% had ≥1 high-risk comorbidity), with vaccination rates of 50% in cases and 70% in controls.
Vaccine effectiveness in preventing hospitalization was 51% (95% CI, 29%–65%) against influenza A(H1N1)pdm09.
Vaccine effectiveness against influenza B-associated hospitalization was 53% (95% CI, 11%–76%), conferring protection across all adult age groups.

Cite This Study

Ferdinands et al. (2018) studied this question.

synapsesocial.com/papers/6a7f4f33375bfe41b7b3d66d https://doi.org/10.1093/infdis/jiy723

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Implication

Test-negative case-control study demonstrates reduced hospitalization risk following influenza vaccination in adults, indicating substantial protection against severe illness in high-risk groups.

Prevention of Influenza Hospitalization Among Adults in the United States, 2015–2016: Results From the US Hospitalized Adult Influenza Vaccine Effectiveness Network (HAIVEN)

Discussion

Member takes

Implication

Key Points

Cite This Study

Prevention of Influenza Hospitalization Among Adults in the United States, 2015–2016: Results From the US Hospitalized Adult Influenza Vaccine Effectiveness Network (HAIVEN)

Discussion

Member takes

Implication

Key Points

Cite This Study

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