Why the study?
Patients with spontaneous thrombosis are often followed for years without proper thrombophilia testing, despite pregnancy carrying a high risk of re-thrombosis and thromboembolic complications.
Early detection of thrombophilia and timely initiation of prophylactic heparin therapy are crucial for preventing thromboembolic complications and obstetric losses in high-risk pregnant women.
Supports considering thrombophilia testing after unprovoked thrombosis; leaves open its role in preventing pregnancy-related events.
The rate of thromboembolic complications associated with thrombophilia is very high; therefore the detection of thrombophilia mutations in the high-risk group of patients is important for the prevention of morbidity, mortality and obstetric losses. The problem of thrombophilia is dealt with by doctors of various specialties: laboratory stuff, geneticists, vascular surgeons, hematologists, neurologists, cardiologists and obstetricians-gynecologists. At the same time, patients with spontaneous thrombosis are followed-up for years without proper examination for thrombophilia. Considering that pregnancy is a condition associated with a high probability of re-thrombosis, it is advisable to determine the cause and tactics of management and treatment of pregnant women as early as possible during the period of pregnancy.
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Melnikov et al. (2021) studied this question.
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