October 8, 2012The Journal of Infectious Diseases
Higher Immunoglobulin G Antibody Levels Against Cytomegalovirus Are Associated With Incident Ischemic Heart Disease in the Population-Based EPIC-Norfolk Cohort
Why the study?
Are higher CMV IgG antibody levels associated with an increased risk of incident ischemic heart disease in immunocompetent individuals?
Population
12,574 participants without ischemic heart disease from the population-based EPIC-Norfolk cohort, aged 40-70…
Comparison
Highest cytomegalovirus immunoglobulin G… vs CMV seronegativity
Design
Cohort
Follow-up
mean 12 years (SD 2.2 years)
Authors
Discussion
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Member takes
Implication
Should not yet inform CMV testing or management; leaves open whether higher IgG levels mark causal IHD risk or require prospective confirmation.
Structured PICO
Are higher CMV IgG antibody levels associated with an increased risk of incident ischemic heart disease in immunocompetent individuals?
P
Population
12,574 participants without ischemic heart disease (IHD) from the population-based EPIC-Norfolk cohort, aged 40-70 years old at recruitment.
I
Intervention
Highest cytomegalovirus (CMV) immunoglobulin G (IgG) antibody levels
C
Comparator
CMV seronegativity
O
Outcome
Incident ischemic heart disease (first-time IHD events resulting in death or hospitalization)hard clinical
Higher CMV IgG antibody levels are independently associated with an increased risk of incident ischemic heart disease in a general population cohort.
Cite This Study
Gkrania‐Klotsas et al. (2012) studied this question.