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May 19, 2009Annals of Internal Medicine

Current Guidelines for Using Angiotensin-Converting Enzyme Inhibitors and Angiotensin II–Receptor Antagonists in Chronic Kidney Disease: Is the Evidence Base Relevant to Older Adults?

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Why the study?

Is the evidence base for using ACE inhibitors and ARBs in chronic kidney disease relevant to adults older than 70 years?

Population

Adults older than 70 years with chronic kidney disease

Design

Review

Authors

AOAnn M. O’HareTwitter (United States)

Discussion

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Implication

Guidelines for ACE inhibitors and ARBs in CKD should not yet guide care in adults over 70; leaves open the need for dedicated trials in this population.

Structured PICO

Is the evidence base for using ACE inhibitors and ARBs in chronic kidney disease relevant to adults older than 70 years?

P
Population
Adults older than 70 years with chronic kidney disease
I
Intervention
Angiotensin-converting enzyme inhibitors and angiotensin II-receptor antagonists
O
Outcome
Representation of older adults in randomized trials underpinning guidelines compared to a representative sample of older adults with chronic kidney disease in the general population

The evidence base supporting the use of ACE inhibitors and ARBs in chronic kidney disease lacks adequate representation of adults over 70, limiting its applicability to this growing demographic.

Cite This Study

Ann M. O’Hare (2009) studied this question.

synapsesocial.com/papers/6a7f6855dc397acca2f209fahttps://doi.org/10.7326/0003-4819-150-10-200905190-00010
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Also Consider

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