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January 1, 2008International Journal of OncologyOpen Access

Role of alternative splicing of periostin in human bladder carcinogenesis

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Population

23 human bladder cancer tissue specimens, 5 normal bladder tissue specimens, 17 human cancer cell lines, and…

Comparison

Ectopic expression of wild-type periostin… vs Control vector or original cancer cells

Design

Preclinical

Authors

CKChul Geun KimHanyang UniversityTITakahiro IsonoShiga University of Medical ScienceYTYukihiro TambeShiga University of Medical Science

Discussion

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Implication

Periostin Variant I lacks metastasis suppression in bladder cancer models; leaves open its role and therapeutic targeting in patients.

Structured PICO

P
Population
23 human bladder cancer tissue specimens (transitional cell carcinomas), 5 normal bladder tissue specimens, 17 human cancer cell lines (including 6 bladder cancer cell lines), and BALB/c-nu/nu female nude mice
I
Intervention
Ectopic expression of wild-type (WT) periostin, Variant I, or Variant II
C
Comparator
Control vector or original cancer cells
O
Outcome
Expression of WT and spliced variants of periostin mRNA, in vitro cell invasiveness, and in vivo lung metastasissurrogate

The loss of wild-type periostin and the emergence of its spliced Variant I are closely associated with bladder cancer development and the loss of metastasis suppression.

Cite This Study

Kim et al. (2008) studied this question.

synapsesocial.com/papers/6a7f6955ae0800d85efbf799https://doi.org/10.3892/ijo.32.1.161
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Periostin is down-regulated in high grade human bladder cancers and suppressesin vitro cell invasiveness andin vivo metastasis of cancer cells2005 · 91 citations
  2. 2Periostin Promotes Invasion and Anchorage-Independent Growth in the Metastatic Process of Head and Neck Cancer2006 · 216 citations
  3. 3Expression and function of periostin‐isoforms in bone2004 · 183 citations
  4. 4Periostin as a Novel Factor Responsible for Ventricular Dilation2004 · 140 citations
  5. 5Effects of Pressure Overload on Extracellular Matrix Expression in the Heart of the Atrial Natriuretic Peptide–Null Mouse2003 · 163 citations