May 6, 2005International Journal of CancerOpen Access

Periostin is down-regulated in high grade human bladder cancers and suppressesin vitro cell invasiveness andin vivo metastasis of cancer cells

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Population

Normal human bladder tissues, human bladder cancer tissues, 3 human bladder cancer cell lines, bladder…

Design

Preclinical

Authors

CKChul Jang KimKoga Hospital NYNaohisa YoshiokaHoward Hughes Medical Institute YTYukihiro TambeShiga University of Medical Science

Discussion

Member takes

Implication

Hypothesis-generating for periostin modulation in bladder cancer; clinical validation required before any therapeutic consideration.

Structured PICO

Population

Normal human bladder tissues (n=5), human bladder cancer tissues (n=33; 11 grade 1, 10 grade 2, 12 grade 3), 3 human bladder cancer cell lines, bladder cancer cell line SBT31A, mouse melanoma cell line B16-F10, and nude mice.

Intervention

Ectopic expression of periostin gene by a retrovirus vector

Outcome

Periostin mRNA expression, in vitro cell invasiveness, cell proliferation, tumor growth, and in vivo lung metastasissurrogate

Periostin acts as a tumor suppressor in human bladder cancer, with its downregulation correlating with higher tumor grade and its expression suppressing invasion and metastasis.

Cite This Study

Kim et al. (2005) studied this question.

synapsesocial.com/papers/6a6f71c7660549caf2c3fc75 https://doi.org/10.1002/ijc.21120

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Periostin is down-regulated in high grade human bladder cancers and suppressesin vitro cell invasiveness andin vivo metastasis of cancer cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Periostin is down-regulated in high grade human bladder cancers and suppressesin vitro cell invasiveness andin vivo metastasis of cancer cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

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