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May 3, 2018The Journals of Gerontology Series AOpen Access

Frailty and Multimorbidity: A Systematic Review and Meta-analysis

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Why the study?

Is multimorbidity associated with frailty in older adults?

Population

78,122 participants from 48 studies (mostly community-dwelling older adults)

Design

Meta-analysis

Authors

DVDavide Liborio VetranoStockholm UniversityKPKatie PalmerEuropean Centre for Disease Prevention and ControlAMAlessandra MarengoniStockholm University

Discussion

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Implication

Supports frailty screening in multimorbid older adults; confirms strong association but leaves causal direction open.

Structured PICO

Is multimorbidity associated with frailty in older adults?

P
Population
78,122 participants from 48 studies (mostly community-dwelling older adults)
O
Outcome
Coexistence of frailty and multimorbidity and their association

Frailty and multimorbidity are highly coexistent and significantly associated in older adults, though the causal direction remains unclear.

Limitations

  • Most studies were cross-sectional, limiting causal inference
  • Moderate risk of bias in 43 of 48 studies
  • High heterogeneity in prevalence estimates

Cite This Study

Vetrano et al. (2018) studied this question.

synapsesocial.com/papers/6a7f696f87803c5a2dba7d9dhttps://doi.org/10.1093/gerona/gly110
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Phenotypic frailty and multimorbidity are independent 18-year mortality risk indicators in older men2021 · 45 citations
  2. 2Research on the frailty status and adverse outcomes of elderly patients with multimorbidity2022 · 48 citations
  3. 3The Impact of Multidimensional Frailty on Adverse Outcomes in Older Adults: A Systematic Review and Meta‐Analysis2026 · 1 citations
  4. 4The association between multimorbidity and intrinsic capacity decline among older adults: the mediating role of frailty2025 · 2 citations
  5. 5The association between multimorbidity patterns and physical frailty among middle-aged and older community-dwelling adults: The mediating role of depressive symptoms2024 · 1 citations