Key result
Phenotypic frailty without multimorbidity increased 18-year mortality risk (HR 1.62) similarly to multimorbidity without frailty (HR 1.55), while their combination strongly predicted mortality (HR 2.93).
Why the study?
Multimorbidity, prefrailty, and frailty are frequent in ageing populations, but their independent relationships to long-term prognosis in home-dwelling older people are not well recognised.
Does phenotypic frailty and multimorbidity predict 18-year mortality in home-dwelling older men?
Population
1365 home-dwelling men with median age of 73 years
Comparison
Frailty, prefrailty, and/or multimorbidity vs nonfrail without multimorbidity
Design
Cohort study
Follow-up
18-year
Authors
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May inform long-term risk stratification in older men; leaves open whether frailty-targeted interventions improve survival.
Cohort (n=1,365)
No
Does phenotypic frailty and multimorbidity predict 18-year mortality in home-dwelling older men?
Hazard Ratio: 1.62 (95% CI 1.13–2.31)
Phenotypic frailty alone is associated with a similar long-term mortality risk as multimorbidity in older men, and their combination synergistically increases mortality risk.
Strandberg et al. (2021) conducted a cohort in Older home-dwelling men (n=1,365). Phenotypic frailty without multimorbidity vs. No prefrailty/frailty and no multimorbidity was evaluated on 18-year mortality (HR 1.62, 95% CI 1.13-2.31). Phenotypic frailty without multimorbidity increased 18-year mortality risk (HR 1.62) similarly to multimorbidity without frailty (HR 1.55), while their combination strongly predicted mortality (HR 2.93).
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