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December 17, 2008Journal of Nuclear MedicineOpen Access

Repeatability of Rest and Hyperemic Myocardial Blood Flow Measurements with 82Rb Dynamic PET

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Why the study?

Is 82Rb dynamic PET reproducible for measuring rest and hyperemic myocardial blood flow in healthy volunteers?

Population

15 healthy volunteers

Design

Cross-sectional

Follow-up

60 minutes

Authors

OMOsamu ManabeKYKeiichiro YoshinagaCKChietsugu Katoh

Discussion

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Overview

Short-term 82Rb PET MBF reproducibility is supported in healthy volunteers; leaves open patient validation and therapeutic monitoring applications.

Structured PICO

Is 82Rb dynamic PET reproducible for measuring rest and hyperemic myocardial blood flow in healthy volunteers?

P
Population
15 healthy volunteers
I
Intervention
Rest and pharmacologic stress 82Rb PET, repeated 60 min apart
O
Outcome
Repeatability of rest and hyperemic myocardial blood flow (MBF) measurementssurrogate

Myocardial blood flow measurements using 82Rb PET are highly reproducible in a same-day short-term protocol, enabling quantification of acute therapeutic effects.

Cite This Study

Manabe et al. (2008) studied this question.

synapsesocial.com/papers/6a7f72d1024876978df6d9dchttps://doi.org/10.2967/jnumed.108.055673
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