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June 6, 2025MedicineOpen Access

Prediction of poor prognosis in patients with sepsis-induced coagulopathy

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Why the study?

The study was conducted to evaluate the prognostic value of procalcitonin, lactate, and sequential organ failure assessment scores in predicting poor outcomes in sepsis-induced coagulopathy and to develop a predictive model.

Does a combined model of PCT, Lac, and SOFA score accurately predict 28-day mortality in patients with sepsis-induced coagulopathy?

Population

96 SIC patients in Hebei General Hospital

Comparison

Survival group vs death group

Design

Observational cohort study

Follow-up

28 days

Authors

RTRuimin TanCGChen GeZYZinan Yang

Discussion

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Member takes

Overview

Should not yet change SIC risk stratification; leaves open external validation of the combined PCT-lactate-SOFA model.

Structured PICO

Does a combined model of PCT, Lac, and SOFA score accurately predict 28-day mortality in patients with sepsis-induced coagulopathy?

P
Population
96 adult patients with sepsis-induced coagulopathy (SIC) admitted to the ICU, meeting Sepsis-3.0 criteria and ISTH 2017 SIC criteria, with a SOFA score ≥ 2.
I
Intervention
Combined predictive model using procalcitonin (PCT), lactate (Lac), and sequential organ failure assessment (SOFA) score
C
Comparator
Individual indicators (PCT, Lac, or SOFA score alone)
O
Outcome
28-day mortalityhard clinical

A combined predictive model incorporating procalcitonin, lactate, and SOFA score effectively predicts 28-day mortality in patients with sepsis-induced coagulopathy, outperforming individual indicators.

Limitations

  • Single-center, retrospective study with a relatively small sample size
  • SIC diagnostic criteria based on Sepsis-3.0 resulted in a smaller cohort compared to other standards

Cite This Study

Tan et al. (2025) studied this question.

synapsesocial.com/papers/6a7f85fde62b38f18e68236fhttps://doi.org/10.1097/md.0000000000042709
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Usefulness of Measuring Changes in SOFA Score for the Prediction of 28-Day Mortality in Patients With Sepsis-Associated Disseminated Intravascular Coagulation2019 · 55 citations
  2. 2The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)2016 · 29,073 citations
  3. 3Relationship between serum sodium level and sepsis-induced coagulopathy2024 · 9 citations
  4. 4Occurrence and adverse effect on outcome of hyperlactatemia in the critically ill2009 · 215 citations