July 18, 2013Journal of Nuclear MedicineOpen Access

Measurement of Human Brown Adipose Tissue Volume and Activity Using Anatomic MR Imaging and Functional MR Imaging

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Why the study?

Can anatomic and functional MR imaging assess human brown adipose tissue volume and activity compared to (18)F-FDG PET/CT?

Population

Human subjects

Comparison

Anatomic MR imaging and functional MR imaging… vs (18)F-FDG PET/CT scans

Design

Cross-sectional

Authors

YCYin‐Ching Iris ChenHarvard University ACAaron M. CypessWest Virginia University YCYih‐Chieh ChenVertex Pharmaceuticals (United States)

Discussion

Member takes

Implication

Supports fMRI feasibility for radiation-free BAT assessment; leaves open validation versus PET/CT before broader adoption.

Structured PICO

Can anatomic and functional MR imaging assess human brown adipose tissue volume and activity compared to (18)F-FDG PET/CT?

Population

Human subjects

Intervention

Anatomic MR imaging and functional MR imaging (fMRI) with mild cold challenge

Comparator

(18)F-FDG PET/CT scans

Outcome

Brown adipose tissue (BAT) volume and functionality (BOLD signal changes)surrogate

MR imaging and fMRI can feasibly assess brown adipose tissue volume and its response to mild cold stimulation in humans.

Cite This Study

Chen et al. (2013) studied this question.

synapsesocial.com/papers/6a7f92cf06444dc1a69fe792 https://doi.org/10.2967/jnumed.112.117275

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Measurement of Human Brown Adipose Tissue Volume and Activity Using Anatomic MR Imaging and Functional MR Imaging

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Measurement of Human Brown Adipose Tissue Volume and Activity Using Anatomic MR Imaging and Functional MR Imaging

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider