Why the study?
Do endothelin antagonists (bosentan or BQ123) reduce blood pressure and improve renal function in rat models of salt-dependent hypertension?
Population
Deoxycorticosterone acetate (DOCA)-salt rats, Dahl salt-sensitive (Dahl-S) rats, and normotensive Wistar rats
Design
Preclinical
Authors
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Endothelin antagonists lower BP without renal benefit in hypertensive rat models; leaves open whether selective ET-A blockade harms GFR in patients.
Do endothelin antagonists (bosentan or BQ123) reduce blood pressure and improve renal function in rat models of salt-dependent hypertension?
In rat models of salt-dependent hypertension, endothelin antagonists effectively lower blood pressure but do not improve, and may temporarily worsen, renal function.
Doucet et al. (1996) studied this question.
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