Population
Glomerular mesangial cells (used as a model to study transmembrane signaling)
Design
Review
Authors
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No immediate change to hypertension care; leaves open whether these endothelin-Ca2+ and phospholipase pathways warrant targeted trials.
This review elucidates the basic science mechanisms of transmembrane signaling induced by endothelin, a potent vasoconstrictor peptide.
Simonson et al. (1990) studied this question.
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