Population
HEK cells expressing Kv7.4 and rat mesenteric arteries/myocytes
Comparison
Morpholino-induced knockdown of KCNE4 or… vs Control (no knockdown or no co-expression)
Design
Preclinical
Authors
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KCNE4 modulation of Kv7.4 sensitivity remains preclinical; leaves open its role in human arterial tone.
KCNE4 plays a fundamental role in regulating the function and expression of Kv7.4 in vascular smooth muscle, influencing arterial tone.
Jepps et al. (2015) studied this question.
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