KCNE4 is an inhibitory subunit to the KCNQ1 channel
Key result
Co-expression of KCNQ1 and KCNE4 completely inhibited the KCNQ1 current in Xenopus oocytes and mammalian CHO-K1 cells, demonstrating that KCNE4 is an inhibitory subunit.
Population
Xenopus oocytes and mammalian CHO-K1 cells
Comparison
Co-expression of KCNE4 vs Absence of KCNE4
Design
Preclinical
Authors
Discussion
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Member takes
Implication
KCNE4 inhibition of KCNQ1 has no immediate clinical implications; extends KCNE modulation knowledge but leaves open in vivo roles in uterus and embryos.
Structured PICO
P
Population
Xenopus oocytes and mammalian CHO-K1 cells
I
Intervention
Co-expression of KCNE4
C
Comparator
Absence of KCNE4
O
Outcome
KCNQ1 currentsurrogate
KCNE4 acts as a specific inhibitory subunit to KCNQ1 channels, completely blocking their current without altering membrane expression.
Cite This Study
Grunnet et al. (2002) studied KCNQ1 channel function. Co-expression of KCNQ1 and KCNE4 vs. KCNQ1 expression alone was evaluated on KCNQ1 current inhibition. Co-expression of KCNQ1 and KCNE4 completely inhibited the KCNQ1 current in Xenopus oocytes and mammalian CHO-K1 cells, demonstrating that KCNE4 is an inhibitory subunit.