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September 9, 2003Hypertension

Angiotensin AT 2 Receptors Directly Stimulate Renal Nitric Oxide in Bradykinin B 2 -Receptor–Null Mice

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Population

Conscious, bradykinin B2-null and wild-type mice (n=8 in each group)

Comparison

Low sodium intake alone or with angiotensin AT1… vs Normal salt intake; wild-type vs B2-null mice…

Design

Preclinical

Authors

PAPeter AbadirRCRobert M. CareyHSHelmy M. Siragy

Discussion

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Overview

No change to ARB use in hypertension; leaves open relative contributions of direct vs B2-mediated AT2-NO pathways in humans.

Structured PICO

P
Population
Conscious, bradykinin B2-null and wild-type mice (n=8 in each group)
I
Intervention
Low sodium intake alone or with angiotensin AT1 receptor blocker (valsartan 0.5 microg/min), AT2 receptor blocker (PD123319 0.15 microg/min), or both
C
Comparator
Normal salt intake; wild-type vs B2-null mice; different blocker combinations
O
Outcome
Renal interstitial, stable NO metabolites and cGMP levels measured by microdialysissurrogate

Nitric oxide can be produced by two alternative pathways: directly through the AT2 receptor or indirectly from AT2 receptor stimulation of bradykinin via the B2 receptor.

Cite This Study

Abadir et al. (2003) studied this question.

synapsesocial.com/papers/6a7f9e5beddba99f883e8845https://doi.org/10.1161/01.hyp.0000090323.58122.5c
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT <sub>2</sub> ) angiotensin receptor1999 · 329 citations
  2. 2The subtype 2 (AT2) angiotensin receptor mediates renal production of nitric oxide in conscious rats.1997 · 484 citations
  3. 3The subtype-2 (AT2) angiotensin receptor regulates renal cyclic guanosine 3', 5'-monophosphate and AT1 receptor-mediated prostaglandin E2 production in conscious rats.1996 · 313 citations
  4. 4Effect of High Salt Intake in Mutant Mice Lacking Bradykinin-B <sub>2</sub> Receptors1997 · 155 citations
  5. 5Normal Blood Pressure and Renal Function in Mice Lacking the Bradykinin B2Receptor2001 · 65 citations