Cardiac risk stratification in cancer patients: A longitudinal patient–patient network analysis

4,632 adult cancer patients referred to the cardio-oncology service at the Cleveland Clinic (US-based), median age 63, 59% female, 84% white. Includes patients with hematologic (39%) and solid tumor (61%) cancers.

Topology-based K-means clustering approach for unbiased patient-patient network analyses (psnCVD) using 112 clinical variables (demographics, echocardiogram, lab testing, cardiac factors) to identify cardiac risk subgroups.

All-cause mortality with up to 20 years' follow-up (median 5.02 years) and 5 diagnosed cardiac outcomes (atrial fibrillation, coronary artery disease, heart failure, myocardial infarction, and stroke) defined as de novo cancer therapy-related cardiac dysfunction (CTRCD).hard clinical