Population
In vivo myocardial infarction heart model and in vitro cardiac fibroblasts
Design
Preclinical
Follow-up
two weeks after MI (in vivo)
Authors
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miR-24 modulation merits further preclinical testing; leaves open translation to human post-MI therapy.
miR-24 attenuates cardiac fibrosis and improves heart function after myocardial infarction by regulating the furin-TGF-β pathway, suggesting a potential therapeutic target.
Wang et al. (2012) studied this question.
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