Population
Conscious rats
Comparison
Aortic baroreceptor denervation or sinoaortic… vs Sham surgery
Design
Preclinical
Follow-up
3 days
Authors
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Transient MAP rise post-barodenervation normalizes without natriuresis in rats; leaves open sympathetic mechanisms for chronic BP control and precludes clinical inference.
Normalization of MAP after barodenervation in rats is not due to pressure natriuresis, but likely a failure to maintain chronic sympathetic activity elevation.
Osborn et al. (1990) studied this question.
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