Persistence of a higher perivascular fat attenuation index on serial cardiac CT may indicate disease deterioration and progression in patients with spontaneous coronary artery dissection.
Persistent high FAI may flag SCAD deterioration but should not yet change practice; leaves open serial FAI for inflammation monitoring.
The perivascular fat attenuation index (FAI) has been recognized as a cardiac computed tomography-based (CCT)-based biomarker of coronary inflammation. We report the case of a 47-year-old woman with acute spontaneous coronary artery dissection (SCAD) involving the proximal left coronary artery (LCA), who underwent FAI three times. The initial CCT scan revealed higher perivascular FAI values in the dissected LCA. The second CCT scan, performed 8 days later, showed persistence of a higher perivascular FAI value only in the left circumflex coronary artery, in which progression of stenotic severity and myocardial infarction formation were found. The persistence of a higher perivascular FAI may indicate disease deterioration in patients with SCAD.
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Yoshihara et al. (2025) studied this question.
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