Why the study?
Heart failure remains a major clinical challenge across phenotypes with high morbidity and mortality, particularly in vulnerable patients with type 2 diabetes or prediabetes.
Do SGLT2 inhibitors improve outcomes in patients with chronic heart failure and type 2 diabetes mellitus?
Do SGLT2 inhibitors improve outcomes in patients with chronic heart failure and type 2 diabetes mellitus?
This review highlights the paradigm shift in managing heart failure in patients with type 2 diabetes, emphasizing SGLT2 inhibitors as foundational therapy across all ejection fractions.
Should not yet change practice; leaves open SGLT2i implementation across HF phenotypes in T2DM and prediabetes.
Despite the successes achieved in diagnosis and treatment, HF, regardless of the phenotype, remains one of the significant problems in the health sector, due to the high incidence, frequency of hospitalization, disability and mortality. In turn, patients with both type 2 diabetes and prediabetes are a vulnerable group in terms of the development of CHF. CH-sFV therapy has been focused for several decades on the treatment of concomitant diseases such as type 2 diabetes, hypertension, coronary heart disease, obesity and, if necessary, initiation of diuretic therapy to improve the quality of life. However, to date, great progress has been made in the treatment of HF-sFV. All guidelines for the management of patients with HF, based on the results of large randomized trials, postulate that iNGLT2 types are the basic drugs for the treatment of patients with HF, regardless of PV. Algorithms of specialized medical care for patients with diabetes recommend the appointment of iNGLT type 2 in the presence or high risk of developing CHF and/or CKD, regardless of the HbA1c level, in patients with type 2 diabetes to reduce the risk of hospitalization for HF, cardiovascular events and reduce the risks of CKD progression.
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Demidova et al. (2023) studied this question.
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