Why the study?
Does sacubitril/valsartan improve measured GFR compared to irbesartan in patients with moderate to severe chronic kidney disease?
Does sacubitril/valsartan improve measured GFR compared to irbesartan in patients with moderate to severe chronic kidney disease?
In patients with moderate to severe chronic kidney disease, sacubitril/valsartan had similar effects on kidney function and albuminuria as irbesartan over 12 months, but significantly reduced blood pressure and cardiac biomarkers.
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No GFR benefit with sacubitril/valsartan versus irbesartan in moderate-severe CKD; confirms similar renal effects despite greater BP reduction.
Haynes et al. (2018) studied this question.
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