Population
Mouse models including PPARdelta mice, mice with adipose tissue-specific deletion of PPARdelta, and APC mice
Comparison
Genetic deletion of PPARdelta vs Wild-type mice
Design
Preclinical
Authors
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PPARdelta's developmental and metabolic roles in mice warrant extreme caution for human targeting; leaves open its functions in clinical metabolism or colorectal neoplasia.
PPARdelta plays specific roles in embryo development and systemic lipid metabolism, but is not required for colorectal tumor establishment.
Barak et al. (2001) studied this question.
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