Key result
Disruption of the murine gene encoding PPARalpha resulted in significant alterations in lipid metabolism but was not associated with an overt obese phenotype.
Population
Two purebred congenic strains of PPARalpha-null mice and wild-type controls, male and female, from 3 to 9…
Comparison
Disruption of the murine gene encoding PPARalpha… vs Wild-type controls.
Design
Preclinical
Follow-up
3 to 9 months of age
Authors
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PPARalpha disruption alters lipid metabolism without obesity in mice; leaves open its human metabolic relevance for translational study.
Disruption of PPARalpha alters lipid metabolism in liver and adipose tissue but does not cause an overt obese phenotype in mice, contradicting earlier studies.
Akiyama et al. (2001) studied Obesity and lipid homeostasis. PPARalpha-null genotype vs. Wild-type controls was evaluated on Weight gain and average body weight. Disruption of the murine gene encoding PPARalpha resulted in significant alterations in lipid metabolism but was not associated with an overt obese phenotype.
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