Key result
The PPARγ-P465L mutation in apolipoprotein E-null mice resulted in unchanged atherosclerotic plaque development due to small, competing pro- and antiatherogenic effects.
The PPARγ-P465L mutation exerts small, competing pro- and antiatherogenic effects that result in unchanged overall plaque development in apolipoprotein E-deficient mice.
Neutral plaque effects in this model leave open net PPARγ impact on human atherosclerosis.
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Pendse et al. (2012) studied Atherosclerosis. PPARγ-P465L mutation vs. Apolipoprotein E-null mice without the mutation was evaluated on Atherosclerotic plaque size or composition. The PPARγ-P465L mutation in apolipoprotein E-null mice resulted in unchanged atherosclerotic plaque development due to small, competing pro- and antiatherogenic effects.
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