Key result
Mice with a dominant-negative PPARgamma mutation (P465L) exhibited reduced brown adipocyte recruitment and decreased nonshivering thermogenic capacity after cold acclimation.
Population
Mice with a dominant-negative peroxisome proliferator-activated receptor gamma (PPARgamma) mutation (P465L)
Design
Preclinical
Authors
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Caution against human PPARgamma therapies; leaves open its necessity for brown fat thermogenesis.
Maintenance of oxidative brown-like adipose tissue is highly dependent on PPARgamma function, which may be relevant for PPARgamma-dependent obesity treatments.
Gray et al. (2006) studied this question. P465L PPARgamma mutation was evaluated on Brown adipocyte recruitment and thermogenic capacity. Mice with a dominant-negative PPARgamma mutation (P465L) exhibited reduced brown adipocyte recruitment and decreased nonshivering thermogenic capacity after cold acclimation.
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