Why the study?
Does prolactin receptor inactivation protect against high-fat-diet-induced obesity in mice?
Population
Mice lacking prolactin receptor (PRLR) on a high-fat diet
Design
Preclinical
Authors
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May identify prolactin receptor as a novel obesity target in rodents; leaves open human translation or therapeutic potential.
Does prolactin receptor inactivation protect against high-fat-diet-induced obesity in mice?
Prolactin receptor inactivation in mice promotes beige adipocyte differentiation and protects against diet-induced obesity, highlighting a novel role for prolactin in energy balance.
Auffret et al. (2012) studied this question.