Why the study?
Does the disruption of growth hormone or prolactin receptors affect adipocyte proliferation and differentiation in mice?
Population
Female prolactin receptor gene disrupted mice, growth hormone receptor gene disrupted mice, and wild-type…
Comparison
Gene disruption of prolactin receptor or growth… vs Wild-type animals
Design
Preclinical
Authors
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Hypothesis-generating for depot-specific adiposity regulation; leaves open translational relevance of PRL/GH signaling to human obesity.
Does the disruption of growth hormone or prolactin receptors affect adipocyte proliferation and differentiation in mice?
In vivo evidence demonstrates that both growth hormone and prolactin stimulate adipocyte differentiation, but growth hormone effects are site-specific and induce intrinsic changes in the precursor population.
Flint et al. (2006) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: